Follistatin 315 1mg

Description

Follistatin 315 is a naturally occurring glycoprotein isoform of follistatin that functions as a high-affinity binding protein for select TGF-β superfamily ligands, including activins, and is studied for its interactions with myostatin-associated signaling. Follistatin-315 protein research commonly examines how ligand sequestration influences cell signaling networks that regulate tissue development, differentiation, and homeostatic responses under controlled laboratory conditions. This isoform is frequently described as a predominant circulating form found in plasma, making it relevant to experimental designs that evaluate soluble binding proteins and extracellular signaling balance.

In vitro studies and animal models have evaluated endpoints such as SMAD pathway activity, changes in gene expression profiles, markers of cell proliferation and differentiation, and shifts in inflammatory-associated signaling relative to controls. Key research areas include skeletal muscle biology and growth-factor signaling assays, developmental biology models involving activin regulation, and mechanistic studies of immune-modulatory signaling pathways. These systems matter in laboratory research because activin–follistatin dynamics are central to experimental investigations of tissue remodeling, endocrine-related signaling, and context-dependent regulation of cellular responses.

For research use only. Not for human consumption.

References:
Sidis Y et al., Endocr Rev, 2001 22(5):726–729
Lee SJ et al., Proc Natl Acad Sci USA, 2001 98(16):9306–9311
Cash JN et al., J Biol Chem, 2009 284(13):9011–9020