Description
FOXO4-DRI is a synthetic peptide designed as a D-amino-acid, sequence-reversed analogue of a FOXO4 interaction motif, commonly used to study FOXO4–p53 binding dynamics in cellular senescence models. FOXO4-DRI peptide research typically evaluates whether competitive disruption of FOXO4–p53 complex formation changes apoptosis-related signaling specifically in senescent cells under controlled laboratory conditions. Because the retro-inverso design can increase resistance to proteolytic degradation relative to all-L peptides, it is also used in stability and exposure–response experiments in vitro and in animal models.
Research commonly focuses on senescence-associated pathways in tissues such as liver, kidney, adipose, and skeletal muscle, as well as immune-cell signaling environments. Major research areas include (1) senescent cell biology and selective clearance mechanisms, (2) p53-regulated transcriptional programs and cell-cycle checkpoints, and (3) inflammatory mediator profiling associated with the senescence-associated secretory phenotype (SASP). These systems matter in laboratory research because they help connect protein–protein interaction control to measurable changes in cell fate decisions and tissue-level biomarkers in preclinical settings.
For research use only. Not for human consumption.
References:
Kirkland JL et al., J Clin Invest, 2017;127(4):1247–1256
Yosef R et al., Aging (Albany NY), 2017;9(8):1758–1777
de Keizer PLJ, Trends Mol Med, 2017;23(9):751–762
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