Follistatin 344 1mg

Description

Follistatin 344 is a recombinant, full-length protein analogue of human follistatin (FST) that is studied as a high-affinity binding protein for select TGF-β superfamily ligands, including activins and myostatin. Follistatin-344 protein research commonly focuses on how ligand sequestration alters downstream signaling networks that regulate cellular proliferation, differentiation, and tissue remodeling under controlled laboratory conditions. As a precursor-length construct, it is also used in experimental settings to examine isoform processing and the functional differences between full-length and shorter follistatin variants.

In vitro assays and animal models have evaluated endpoints such as SMAD pathway activity, transcriptional changes in activin/myostatin-responsive genes, markers of myogenesis and extracellular matrix remodeling, and cytokine-associated signaling readouts relative to controls. Major research areas include skeletal muscle signaling models, activin-regulated developmental and endocrine biology studies, and mechanistic investigations of inflammation- and fibrosis-associated pathways. These systems are central to laboratory research because they help characterize how extracellular ligand availability can shift cell-state decisions and tissue-level phenotypes in preclinical models.

For research use only. Not for human consumption.

References:
Lee SJ et al., Proc Natl Acad Sci USA, 2001 98(16):9306–9311
Cash JN et al., J Biol Chem, 2009 284(13):9011–9020
Sidis Y et al., Endocr Rev, 2001 22(5):726–729