PNC-27 5mg

Description

PNC-27 is a research peptide composed of a p53–MDM2 binding domain linked to a membrane-targeting sequence (residues 12–26 of the p53 protein). It has been shown in preclinical studies to interact with cancer cell membranes through HDM-2–associated mechanisms, leading to selective pore formation and membrane destabilization. PNC-27 is utilized in experimental oncology research to investigate peptide–membrane interactions, apoptotic signaling, and tumor-selective cytolytic activity in vitro.

For research use only. Not for human consumption.

References:
Sotomayor EM et al., Int J Cancer, 2005 115(5):701–709
Arora V et al., J Cell Biochem, 2013 114(3):664–671
Hu W et al., Oncotarget, 2017 8(29):47425–47436